Endocrine Abstracts

Background: Adrenal crisis is a life threatening emergency with an incidence of 5–10 adrenal crises/100 patient-years with mortality around 0.5/100 patient-years.Objective: Audit of inpatient adrenal crisis management was undertaken in line with Society for Endocrinology (SFE) guidance 2016 (Trust audit No:9763).Methods: Retrospective evaluation of electronic and paper case records of 2 years (January 2017–December 2018)....

Background: British Association of Thyroid and Endocrine Surgeons defines post-operative hypocalcaemia as adjusted calcium of < 2.0 mmol/l; ‘late hypocalcaemia’ as the ongoing requirement for calcium/Vitamin D supplements at 6 months; permanent post-surgical hypoparathyroidism (PSHP) at 12 months. The incidence rates of late hypocalcaemia are 6.5–12.1% and PSHP is 0.9%–4.5%.Objective: To evaluate PSHP incidence rate in total thyro...

Background: Premature Ovarian Insufficiency (POI) is characterised by oligo-/amenorrhoea with elevated gonadotropins and low oestradiol before the age of 40 years.Objective: To evaluate management of non-Turner POI patients in line with European Society of Human Reproduction and Embryology (ESHRE) guidance (1)Methods: Retrospective evaluation of electronic and paper case records.Results: Over 23-year period (...

Background: Primary adrenal insufficiency (PAI) can be of autoimmune origin (Addison’s disease, AD) or due to inborn disorders of steroidogenesis (congenital adrenal hyperplasia, CAH). Prognosis of patients with PAI has improved considerably after glucocorticoid replacement therapy became available. However, even in recent years, an increased risk of death has been described in both AD and CAH patients. Moreover, even with the current state-of-the-art replacement therapy,...

Background: TS, resulting from partial or complete loss of an X-chromosome, is a rare diagnosis1. In addition to its well-described phenotypic features2, a number of multi-systemic conditions may develop over the lifespan of a Turner female that require long-term surveillance which is challenging to deliver in today’s ‘specialised’ services NHS.Aim: To evaluate UHL service provision against the only guidelines for the...

Background: Small frequent meals are often recommended for weight loss, with supporting evidence often provided from studies in diabetes. Dietary meal content is also relevant, as high fat meals cause systemic inflammation via gut derived bacteria, endotoxin. As such, repeated meals may exacerbate this. In contrast, dietary induced thermogenesis, related to meal size, may reduce with small frequent meals.Aim: Therefore, the aim of this study was to compa...

Introduction: Osteogenesis imperfecta (OI) is a rare, heterogeneous, genetic connective tissue disorder that manifests clinically as bone fragility, brittleness and growth disorder. Effective diagnosis is important (although often challenging) to enable institution of early and effective multidisciplinary management.The case: A 19-year-old woman was referred to the Endocrine clinic at the Warwickshire Institute for the Study of Diabetes, Endocrinology an...

Introduction: Over 9000 bariatric surgeries are conducted annually in the UK and post-operative micronutrient deficiency is common. We report a case of dry beriberi secondary to thiamine deficiency following Roux-en-Y bypass surgery.Case presentationA 45-year-old Caucasian obese lady (155 kg, BMI 57) presented with progressive proximal limb weakness, upper and lower limb paraesthesia, ataxia and athetoid tremors 18 months following...

Aim: Manipulation of human brown adipose tissue (BAT) represents a novel therapeutic option for diabesity. The aim of our study was to develop and test a novel magnetic resonance imaging (MRI) based method to identify human BAT and delineate it from white adipose tissue (WAT), and validate it by providing immunohistochemical confirmation.Methods: Initial scanning with 18F-FDG PET–CT radiotracer uptake on a 25-year-old Caucasian female wit...

Aims: Our aim was to explore predictive factors for the pleiotropic responses to exenatide during the first 12 weeks of therapy, and associations between these responses.Methods: This was an observational study based on patients (n=83) with type 2 diabetes mellitus (T2D) in whom exenatide had been added to existing oral hypoglycaemic therapy. Exenatide was administered subcutaneously (5 mcg bd for the first month, 10 mcg bd thereafter). Data colle...